La Boca is located in the south of the city and its history tied to immigration and tango makes it one of the most picturesque areas. Many Italians who came to Argentina in search of a better life established their corrugated iron houses near the Riachuelo.

The neighborhood still has streets with cobble stones, such as the Caminito, now converted into a footpath that recreates the tenements of times of old with their striking colors and windows hung with laundry. Artists and craftsmen sell tango and neighborhood-related paintings and souvenirs there.

Actors dressed as "gallants" sing songs made famous by Gardel accompanied by a guitar or bandoneón (a type of accordion), while just a little further down a dancing couple astounds the passersby with a milonga. From the promenade that follows the riachuelo you can see the remains of abandoned ships and the Nicolás Avellaneda Bridge which Benito Quinquela Martin immortalized in his paintings.

The studio of the already deceased artist was converted into the La Boca Museum of Fine Arts where the paintings of Quinquela Martin and other painters are exhibited.
La Boca is also the birthplace of one of Argentina's passions: the Boca Juniors soccer club. In the area surrounding the stadium, which is known as the "Bombonera" (the candy jar), the team's blue and yellow colors are omnipresent, as are the murals with themes related to soccer as well as to neighborhoods. All these paintings are the works of "Grupo Murosur" on Brandsen street and Pérez Celis and Macció on Iberlucea street.