Casa Grande Hotel Resort & Spa is, without doubts, the best option of hotel in Guarujá, it is considered to be a 5-star hotel. They are also members of "The Leading Hotels of the World". It is a two-storey building in an authentic Brazilian colonial style, facing the beach of Praia da Enseada, and was inaugurated in 1972. The hotel is situated in 40.000m2 of lush tropical gardens with swaying palm trees. There is one indoor and outdoor heated swimming pool, terraces with ocean or garden view, helipad, three lighted tennis courts, coffee shop, store, fitness center, sauna, complete beach service, multi-sport ground for soccer/volley ball, play ground, parking, full-service spa featuring aesthetic and therapeutic treatments, nine dining and lounge areas (Thai Restaurant, Chibata Restaurant, Cachalote Restaurant, Coffee shop, Music Lounge Bar, Lobby Bar, Pool Bar, Beach Bar, and Spa Restaurant), 2.400m2 of conference and meeting facilities and an additional area of 4.000m2 for trade fairs and exhibitions.

The Casa Grande Hotel features 269 guest rooms divided in six categories with following differences: Premium – with a living area of 25m2, two twin beds or one queen size and lateral view of the street. Premium Superior – with a living area of 27m2, two twin beds or one queen size and lateral view of the street. Luxo – with a living area of 29m2, bathtub, two twin beds or one queen size and view of the garden. Luxo with verandah – with a living area of 29m2 + 7m2 of the verandah, bathtub, two twin beds or one queen size and view of the garden. Luxo Superior – with a living area of 32m2, bathtub, DVD & TV (29"), one king sized bed and lateral view of the swimming pool, but no verandah. Suite Master with verandah – with a living area of 36m2, living room with DVD player, TV (29"), high speed internet access, bathtub, one king sized bed and lateral view of the swimming pool.

All rooms are: decorated with contemporary designer furnishings, marble bathroom with vanity mirror, telephone with voice mail, refrigerator, air conditioning, private safety box, cable TV, hair dryer, complimentary toiletries, AM/FM clock radio, and smoke detector. All rooms have space for an extra bed or cradle, except Luxo Superior & Master.